Yes, our software (GS RichCopy 360 Enterprise) can copy to Nasuni and is cache aware. Once you set the option to let it know that cache. It would periodically check the available cache (configurable settings) and then if cache is below a certain threshold (configurarable setting), then it would pause and keeps on checking to see when it is free again. At which point it would start automatically. No user intervention is required.
Please watch the video in this page to show you how to setup the cache setting.
Nasuni serves as an SMB NAS file share that is hosted on-prem with an active cache available locally. However, all data is pushed out to a cloud storage backend